Other research has shown that TSH levels are lower in people with type 1 narcolepsy.īoth orexin and thyroid hormones influence metabolism and directly affect metabolic activity in brown adipose tissue (brown fat). Research suggests that orexin may affect the release of thyrotropin-releasing hormone in the hypothalamus. The connection between orexin and thyroid hormones is not fully understood, but there is evidence that the two are closely related. Orexin, on the other hand, is produced by cells in the hypothalamus and exists throughout the brain and cerebrospinal fluid. TSH causes the thyroid to make the thyroid hormones triiodothyronine (T3) and thyroxine (T4). The hypothalamus secretes thyrotropin-releasing hormone, which causes the pituitary gland to secrete TSH. The hypothalamus controls these functions by affecting the secretion of thyroid hormones and orexin that is deficient in people with type 1 narcolepsy. Narcolepsy and thyroid function both involve the hypothalamus, a part of the brain involved in controlling metabolism, appetite, temperature regulation, and other important bodily functions. Hypothyroidism, Narcolepsy, and the Hypothalamus Research has shown that type 1 narcolepsy is associated with a variety of autoimmune and allergic conditions, including thyroid dysfunction. In addition, having one autoimmune condition is a risk factor for developing additional autoimmune diseases. Several types of hypothyroidism are caused by autoimmune disease, including Hashimoto’s thyroiditis. This is believed to be due to autoimmune disease. Type 1 narcolepsy is caused by the loss of neurons (brain cells) that secrete orexin (a messenger protein, also called hypocretin) in the hypothalamus. They can both be caused by autoimmune disease, they can both involve the hypothalamus, and they may both affect the metabolism of brown fat.īoth hypothyroidism and narcolepsy can be caused by autoimmune disease, which is when your immune system accidentally views your body as a threat and attacks it instead of protecting it. However, the similarities between hypothyroidism and narcolepsy go beyond sharing symptoms. It is very easy to rule out thyroid problems in people with symptoms such as difficulty sleeping, tiredness, and depression. Thyroid function tests are now used regularly to diagnose both hypothyroidism and hyperthyroidism. Before modern thyroid function tests were developed, narcolepsy was regularly misdiagnosed as hypothyroidism. Hypothyroidism and narcolepsy share many similarities. Similarities Between Hypothyroidism and Narcolepsy Synthetic thyroid hormones replace the hormones normally produced by the thyroid. The main treatment for hypothyroidism is medication. If left untreated, hypothyroidism can lead to many serious complications, such as heart problems, mental health issues, an enlarged thyroid gland, and myxedema (a life-threatening condition). Hypothyroidism in children and teens can cause physical and mental developmental delays. Other symptoms of hypothyroidism include: Symptoms of hypothyroidism include some of the same symptoms seen in narcolepsy, including: Surgery or radiation to treat an overactive thyroid ( hyperthyroidism) or cancer, as well as inflammation from infection or autoimmune disease, can also lead to hypothyroidism. There are many causes of hypothyroidism, including damage to the thyroid, iodine deficiency, and lack of thyroid-stimulating hormone (TSH) from the pituitary gland in the brain. Hypothyroidism occurs when the thyroid gland fails to produce enough thyroid hormones.
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